If you are thinking of creating a web-based startup, it is suggested that you review the following podcasts.
The first is from Jason Calacanis ( @Jason on Twitter) via thisweekin.com
The second is from Jason Fried ( @jasonfried on Twitter) and David Heinemeier Hansson (@DHH on Twitter) via the Signal Vs. Noise blog.
Note: There is some language that may not suitable for all audiences.